Environmental factor

Exposome and Environmental Factors

• Cancer is influenced by environmental factors.
• Exposome complements the genome and includes various environmental exposures.
• Maternal metabolic exposures impact fetal growth.
• No standard way to measure environmental exposures currently exists.
• Research initiatives like the HELIX project and Exposomics project aim to measure the exposome.
• Proposed Human Exposome Project (HEP) similar to the Human Genome Project lacks clarity and support.
• Molecular pathological epidemiology integrates molecular pathology and epidemiology to study the exposome’s impact on disease development.
• Metabolomics helps identify metabolic changes due to environmental exposures.

Socioeconomic Drivers and Climate Change

• Socioeconomic factors can drive climate change.
• Global demand for resources like timber and agricultural crops affects land use change.
• International trade agreements and biofuel development mandates influence land use changes.
• Household-level decisions, like crop substitutions, impact local ecosystems.
• The implications of socioeconomic drivers cascade down to affect land, resources, and the environment.

Maternal Exposome and Offspring Health

• Maternal metabolic exposome influences offspring health, including weight and obesity.
• Environmental factors during pregnancy can have long-term effects on offspring health.
• Gestational diabetes impacts offspring’s growth up to 6 years old.
• Understanding the maternal exposome is crucial for preventing health issues in offspring.

Type 2 Diabetes and Environment

• Environment-wide association studies explore the impact of environmental factors on type 2 diabetes.
• Interaction effects between genetics and environment play a role in type 2 diabetes.
• Environmental factors significantly contribute to the development of type 2 diabetes.
• Analyzing environment-genome associations is essential in understanding type 2 diabetes.

Exposure Biology and Environmental Health

• Exposure biology centers are crucial for studying gene-environment interactions.
• Exposure science tracks daily doses of environmental toxins.
• The exposome concept emphasizes the importance of environmental exposures.
• Integrating exposure science enhances environmental health research.
• Environmental exposure science plays a key role in understanding health impacts.

Environmental factor Data Sources