11-Nor-9-carboxy-THC

11-Nor-9-carboxy-THC is a metabolite of THC, the main psychoactive component of cannabis. It is produced in the body after THC is consumed and is commonly used as a marker for cannabis use in drug testing. 11-Nor-9-carboxy-THC is not psychoactive and is excreted from the body through urine.

Metabolism and Detection:

• 11-COOH-THC formed by oxidation of 11-OH-THC
• Metabolized by conjugation with glucuronide
• Long half-life in the body, detectable for days or weeks
• Selective tests distinguish between 11-OH-THC and 11-COOH-THC
• Presence of 11-COOH-THC indicates past cannabis use

Effects:

• 11-COOH-THC lacks psychoactive effects
• May contribute to analgesic and anti-inflammatory effects of cannabis
• Moderates effects of THC, influencing subjective effects
• Difference in effects seen between occasional and regular users
• Role in determining cognitive and motor impairment

Legal Status:

• Varies among jurisdictions
• Schedule 8 prohibited substance in Western Australia
• Controlled Drug with restrictions to reduce abuse
• Possession or sale in the US subject to prosecution under Analog Act
• Presence may lead to driving while intoxicated charges

Regulation in Australia:

• 11-COOH-THC is a Schedule 8 prohibited substance
• Classified under the Poisons Standard
• Restrictions on manufacture, supply, and possession
• Aim to reduce abuse, misuse, and dependence
• Part of measures to control substance availability

Regulation in the United States:

• Considered similar to Schedule I controlled substance THC
• Possession or sale could lead to prosecution under Federal Analog Act
• Legal consequences for presence of 11-COOH-THC
• Analogous to blood alcohol level for impaired drivers
• Criticized for potential prohibition impact on recent cannabis users

11-Nor-9-carboxy-THC Data Sources