Tetrahydrocannabutol

Pharmacological Properties of Tetrahydrocannabutol (THCB):

• THCB has affinity for human CB1 (i = 15 nM) and CB2 receptors (i = 51 nM) similar to THC.
• In vivo formalin test demonstrated potential analgesic and anti-inflammatory properties of THCB.
• Tetrad test in mice indicated partial agonistic activity of THCB towards CB1 receptor.
• THCB is less commonly found in cannabis samples compared to THC or THCV.
• University of Rhode Island analysis showed that THC-Butyl had 81% protease inhibitor activity against COVID-19 compared to antiviral drug GC376.

Chemistry of Tetrahydrocannabutol (THCB):

• Like THC, Δ9-THCB has 7 double bond isomers and 30 stereoisomers.
• The Δ isomer is known as JWH-130, a synthetic cannabinoid.
• Cannabidibutol (CBDB) is a ring-opened analogue of Δ9-THCB.
• THC-Butyl can be synthesized from 4-Butylresorcinol.
• Chemical codes for Δ9-THCB are JWH-130 and CBDB.

Legal Status of Tetrahydrocannabutol (THCB):

• THCB is not internationally scheduled under the Convention on Psychotropic Substances.
• It may be controlled under analogue law in some jurisdictions as a homologue of THC.

Related Terms and Analogues of Tetrahydrocannabutol (THCB):

• Related terms include Cannabis, Cannabinoid, Hexahydrocannabutol, Parahexyl, and Perrottetinene.
• Additional terms are Tetrahydrocannabihexol and Tetrahydrocannabiphorol.

Research and Studies on Tetrahydrocannabutol (THCB):

• Studies by various authors have explored the properties and synthesis of THC-Butyl.
• Research articles have focused on the pharmacological activities and chemical structure of Δ9-THCB.
• Some studies have investigated the metabolism and potential medical applications of THCB.
• Other sources have discussed the legal status and analogues of THCB.
• A study identified inhibitors of SARS-CoV-2 main protease from a library of minor cannabinoids, including THCB.

Tetrahydrocannabutol Data Sources