8,11-Dihydroxytetrahydrocannabinol

8,11-Dihydroxytetrahydrocannabinol (8β,11-diOH-Δ9-THC) is an active metabolite of THC, the main active component of cannabis. The 8β enantiomer retains psychoactive effects in animal studies with only slightly lower potency than THC, while the 8α enantiomer is much weaker. Both enantiomers have a shorter half-life in the body than 11-Hydroxy-THC, making 8,11-dihydroxy-THC potentially useful for drug testing to distinguish between recent cannabis use and use longer in the past.

Metabolites of Delta-9-Tetrahydrocannabinol

• 3-Hydroxy-THC
• 7-Hydroxycannabidiol
• 11-Hydroxy-Delta-8-THC
• 11-Nor-9-carboxy-THC
• 8,11-Dihydroxytetrahydrocannabinol

Research and Publications

• Pitt CG, Fowler MS, Sathe S, Srivastava SC, Williams DL (June 1975). Synthesis of metabolites of delta-9-tetrahydrocannabinol. Journal of the American Chemical Society. 97 (13): 3798–3802. doi:10.1021/ja00846a040. PMID1141589.
• Järbe TU, Mathis DA (1991). Discriminative stimulus functions of cannabinoids/cannabimimetics. Drug Discrimination: Applications to Drug Abuse Research. NIDA Research Monograph. pp.75–99. PMID1369683.
• Gasse A, Pfeiffer H, Köhler H, Schürenkamp J (January 2018). 8β-OH-THC and 8β,11-diOH-THC-minor metabolites with major informative value?. International Journal of Legal Medicine. 132 (1): 157–164. doi:10.1007/s00414-017-1692-5. PMID28983686. S2CID19208736.

Potential Significance of 8,11-Dihydroxytetrahydrocannabinol

• Could have major informative value in research
• Possible implications for legal medicine and drug abuse research

Related Cannabinoids

• Cannabitriol

8,11-Dihydroxytetrahydrocannabinol Data Sources