Cis-THC

Cis-THC refers to specific isomers of THC, including psychoactive enantiomers and others that retain activity at targets like GPR18 and GPR55. Research on cis-THC covers its synthesis, natural occurrence, chirality, and pharmacological effects, including studies on its importance in Cannabis sativa. Chemical synthesis explores methods like Brønsted acid catalyzed asymmetric synthesis and high-pressure Diels-Alder approaches. This compound’s study is crucial for understanding the diverse effects and potential applications of cannabinoids in cannabis.

Cis-THC Isomers:

• (6aR,10aR) and (6aS,10aR) enantiomers are psychoactive
• Other isomers retain activity at targets like GPR18 and GPR55
• Four cis/trans isomers exist
• Different enantiomers have varying effects
• Specific isomers interact with different receptors

Research Publications:

• Studies on the importance of phenolic hydroxyl group in tetrahydrocannabinols
• Exploration of Δ1-3, 4-cis-tetrahydrocannabinol in Cannabis sativa
• Synthetic tetrahydrocannabinol research in forensic sciences
• High-pressure methods for synthesizing cannabinoid derivatives
• Total synthesis of Δ9-tetrahydrocannabinols using stereodivergent approaches

Natural Occurrence and Chirality:

• Δ-cis-Tetrahydrocannabinol’s natural presence and pharmacology
• Research on the chirality of cis-Tetrahydrocannabinol
• Studies on the pharmacological effects of cis-Tetrahydrocannabinol
• Understanding the chiral properties of cis-Tetrahydrocannabinol
• Exploration of natural sources of cis-Tetrahydrocannabinol

Chemical Synthesis:

• Brønsted acid catalyzed asymmetric synthesis of cis-Tetrahydrocannabinoids
• High-pressure Diels-Alder approach for synthesizing hydroxy-substituted 6a-cyano-tetrahydro-6H-benzo[c]chromen-6-ones
• Access to Δ9-cis- and Δ9-trans-tetrahydrocannabinols family through high-pressure methods
• Stereodivergent total synthesis of Δ9-tetrahydrocannabinols using specific techniques
• Various chemical methods for synthesizing cis-Tetrahydrocannabinoids

Cis-THC Data Sources