Cannabigerolic acid [CBGA]

Cannabigerolic acid (CBGA) is recognized as the “mother” cannabinoid, the precursor from which many cannabinoids are synthesized, including THC and CBD. It plays a crucial role in the biosynthesis of cannabis compounds, undergoing various enzymatic transformations within the plant. CBGA has also shown potential pharmacological benefits, such as anticonvulsant effects in specific epilepsy models.

CBGA and COVID-19

• CBGA demonstrated the second-highest 3C-like protease inhibitor activity against COVID-19 in a study.
• CBGA, CBDA, and THCA exhibited potential in preventing SARS-CoV-2 infection.
• CBGA effectively blocked infection by different strains of SARS-CoV-2 at micromolar concentrations.
• CBGA was the only cannabinoid capable of allosteric binding in addition to orthosteric binding.
• Efficacy results of CBGA against COVID-19 are pending replication in animal models or clinical trials.

CBGA Biosynthesis and Pharmacological Properties

• CBGA serves as a precursor to Delta-9-tetrahydrocannabinol in Cannabis plants.
• The combination of olivetolic acid and geranyl diphosphate forms CBGA in Cannabis.
• Enzymes like CBCA synthase, CBDA synthase, and THCA synthase convert CBGA into CBCA, CBDA, and THCA.
• THC and CBD are derived from the decarboxylation of THCA and CBDA.
• CBGA has demonstrated emerging pharmacological properties, including anticonvulsant effects in epilepsy models.

Cannabigerolic Acid References

• Information on CBGA can be accessed on PubChem.
• Analytical chemistry of Cannabis delves into CBGA.
• The biosynthesis of cannabinoids involves CBGA.
• Studies have highlighted CBGA’s effects on seizures in mouse models of epilepsy.
• CBGA has been identified as a potential SARS-CoV-2 main protease inhibitor.

Further Reading on Cannabigerolic Acid

• A Leafly article provides insights into CBGA and its functions.
• Public domain material from the National Institutes of Health offers more information on CBGA.
• Additional sources can be explored to deepen understanding of CBGA.
• Research papers and studies on CBGA’s properties and effects are recommended for further exploration.
• Stay updated on the latest findings and developments related to CBGA through reputable sources.

Summary and Recommendations

• CBGA shows promising potential in inhibiting COVID-19 and possesses significant pharmacological properties.
• Understanding the biosynthesis and references related to CBGA is crucial for comprehensive knowledge.
• Further exploration through additional reading and research is advised to stay informed about CBGA’s capabilities and applications.

Cannabigerolic Acid Data Sources