Cannabitriol

Cannabitriol, identified in cannabis and as a THC oxidation product, was first isolated in 1966. While its pharmacology is minimally explored, it’s known to act as an antiestrogen and aromatase inhibitor. This minor phytocannabinoid contributes to the diverse chemical profile of cannabis.

Chemical Composition of Cannabitriol

• Cannabitriol is a cannabinoid found in Cannabis sativa L.
• Studies have isolated and characterized (+)-cannabitriol and (-)-10-ethoxy-9-hydroxy-delta 6a[10a]-tetrahydrocannabinol as new cannabinoids from Cannabis sativa L. extract.
• The structure of cannabitriol has been elucidated in scientific literature.

Research Studies on Cannabitriol

• Scientific research has been conducted on the constituents of the hemp plant, including Cannabitriol.
• Studies have explored the potential of cannabinoids like Cannabitriol as aromatase inhibitors for anti-cancer activity.
• Induced fit docking and automated QSAR studies have revealed the ER-α inhibitory activity of Cannabis sativa, including Cannabitriol, in breast cancer.

References and Publications

• Various scientific papers and journals have published research findings on Cannabitriol.
• References include studies on the constituents of the hemp plant, the structure of Cannabitriol, and its isolation and characterization.
• Publications have also explored the instability and poor recovery of cannabinoids in biological samples like urine, oral fluid, and hair.

Potential Medical Applications of Cannabitriol

• Research suggests that Cannabitriol and other cannabinoids from Cannabis sativa L. may have potential anti-cancer properties.
• Studies have investigated the use of Cannabitriol as a potential aromatase inhibitor and its role in inhibiting ER-α activity in breast cancer.
• Cannabitriol and other cannabinoids are being explored for their therapeutic potential in cancer treatment.

Future Research and Patents

• Recent patents and studies have focused on the anti-cancer drug discovery potential of cannabinoids like Cannabitriol.
• Ongoing research is exploring the molecular modeling and screening of Cannabitriol for anti-cancer activity.
• Future studies may delve deeper into the mechanisms of action and therapeutic applications of Cannabitriol in the field of oncology.

Cannabitriol Data Sources