11-Hydroxy-THC

11-Hydroxy-THC is a metabolite of THC that is produced in the liver after consuming cannabis. It is more potent than THC and can produce stronger psychoactive effects. 11-Hydroxy-THC is believed to contribute to the delayed onset and prolonged duration of effects experienced when consuming edibles compared to smoking cannabis.

Pharmacology of 11-Hydroxy-THC

• Acts as a partial agonist at the CB cannabinoid receptor with higher binding affinity than Δ-THC.
• Displays similar cAMP inhibition efficacy to Δ-THC but with a lower maximum response.
• Can be assayed in drug tests.
• Levels are typically higher when consumed orally compared to inhalation.
• Formed in the body after THC consumption and further metabolized into inactive compounds.

Research on 11-Hydroxy-THC

• In vitro analysis showed significant protease inhibitor activity against COVID-19.
• Activity was lower compared to the antiviral drug GC376.
• Conducted by the University of Rhode Island on cannabinoids.
• Shows potential antiviral properties.
• Among the cannabinoids tested in the study.

Related Compounds and Topics

• Related compounds include 11-Hydroxy-Delta-8-THC and 11-Hydroxyhexahydrocannabinol.
• Other relevant compounds like 3-Hydroxy-THC and 7-Hydroxycannabidiol are mentioned.
• Cannabis edibles and Delta-11-Tetrahydrocannabinol are related topics.
• Compounds of interest include 11-OH-CBN and 8,11-Dihydroxytetrahydrocannabinol.
• Formation and metabolism of these compounds are discussed in the references.

Bioanalytical Procedures and Studies

• Several bioanalytical procedures have been developed for determining drugs of abuse in blood.
• Pharmacokinetics and metabolism of cannabinoids like delta9-tetrahydrocannabinol are well-documented.
• Exogenous cannabinoids can act as substrates, inhibitors, and inducers of human drug metabolizing enzymes.
• Detailed studies on the pharmacokinetics and pharmacodynamics of cannabinoids are available.
• Implications of plasma concentrations of THC, 11-hydroxy-THC, and other compounds in chronic cannabis smokers have been investigated.

11-Hydroxy-THC Data Sources