7-Hydroxycannabidiol

7-Hydroxycannabidiol (7-OH-CBD) is an active metabolite of cannabidiol, generated in the body from cannabidiol by the action of the enzyme CYP2C19. While methods have been developed for its synthetic production, and measurement of levels in the body following consumption of cannabidiol, its pharmacology has been relatively little studied, though it has been found to possess similar anticonvulsant effects to cannabidiol itself, as well as lowering blood triglyceride levels. Like its precursor CBD, it is not known to exhibit any psychoactive effects on the body and is known to counter the psychoactive effects of THC if it is present at the same time. This mode of action in 2015 was discovered to be at least contributing in part by being a non competitive negative allosteric modulator of the Cannabinoid receptor type 1.

Cannabinoids Related to Cannabidiol:

• 4-Fluorocannabidiol
• 8,9-Dihydrocannabidiol
• 8,11-Dihydroxytetrahydrocannabinol
• 11-Hydroxy-THC
• Cannabidiolic acid

Research References on Cannabidiol:

• Vlad RA, Hancu G, Ciurba A, Antonoaea P, Rédai EM, Todoran N, Silasi O, Muntean DL (October 2020). Cannabidiol – therapeutic and legal aspects.
• Tchilibon S, Mechoulam R (October 2000). Synthesis of a primary metabolite of cannabidiol.
• Pérez-Acevedo AP, Busardò FP, Pacifici R, Mannocchi G, Gottardi M, Poyatos L, Papaseit E, Pérez-Mañá C, Martin S, Di Trana A, Pichini S, Farré M (December 2020). Disposition of Cannabidiol Metabolites in Serum and Urine from Healthy Individuals Treated with Pharmaceutical Preparations of Medical Cannabis.

Cannabidiol Derivatives:

• Cannabidiol dimethyl ether
• Delta-6-Cannabidiol
• HU-308
• HU-320
• KLS-13019

Journal Citations:

• Die Pharmazie. 75 (10): 463–469. doi:10.1691/ph.2020.0076 (inactive 31 January 2024). PMID33305718.
• Organic Letters. 2 (21): 3301–3. doi:10.1021/ol006369a. PMID11029195.
• Pharmaceuticals (Basel, Switzerland). 13 (12): 459. doi:10.3390/ph13120459. PMC7763054. PMID33322849.

7-Hydroxycannabidiol Data Sources