Cannabidiol [CBD]

Medical Uses of Cannabidiol:

• CBD is a phytocannabinoid found in cannabis plants.
• Clinical research on CBD includes studies on anxiety, addiction, psychosis, movement disorders, and pain.
• CBD is sold as a dietary supplement with unproven therapeutic claims.
• Limited evidence of neurological effects of CBD in humans.
• FDA approves Epidiolex for epilepsy treatment.
• Studies show Epidiolex is effective for treating epilepsy.
• Research on other neurological disorders is inconclusive.
• FDA warns about unknown effects of CBD during pregnancy and breastfeeding.

Non-Intoxicating Effects and Side Effects of CBD:

• CBD does not produce psychoactive effects like THC.
• CBD under research for anti-anxiety and anti-psychotic effects.
• Common side effects of CBD include tiredness, sedation, and changes in appetite.
• FDA expresses concerns about CBD safety, including liver injury.
• Increase in CBD-induced illness reports to poison control centers.
• FDA warns about potential harm to the male reproductive system from CBD.

Research and Interactions of Cannabidiol:

• Federal illegality in the U.S. has hindered CBD research.
• CBD may reduce adverse effects of THC at high doses.
• Laboratory evidence suggests CBD may increase THC availability to receptors.
• CBD inhibits voltage-dependent sodium and potassium channels affecting neural activity.
• CBD partially inhibits the hydroxylation of THC in a clinical trial.
• CBD decreases clobazam metabolism and inhibits certain liver enzymes.

Veterinary Medicine and Pharmacokinetics of CBD:

• Surge in research on CBD and cannabinoids in pets.
• Limited controlled studies show no significant decrease in seizures with CBD in dogs.
• CBD oral bioavailability varies across species.
• Dogs absorb cannabidiolic acid (CBDA) better than CBD post oral ingestion.
• CBD metabolites differ in humans and dogs.
• CBD acts on various receptors and channels in the body.

Legal Status and Regulations of Cannabidiol:

• Australia, Canada, New Zealand, and Sweden allow the medical use of CBD.
• Various regulations exist in different countries regarding the sale and use of CBD products.
• CBD and other cannabinoids classified as novel foods by the European Commission in 2019.
• Hong Kong proposed a complete ban on cannabidiol in 2022.
• Legal ambiguity regarding CBD in countries like the Czech Republic, Russia, and Singapore.

Cannabidiol Data Sources