Cannabichromene [CBC]

Cannabichromene (CBC) is synthesized from CBGA in the cannabis plant, becoming CBCA before decarboxylation produces CBC. It affects THC’s psychoactivity, acts on TRPV1 and TRPA1 receptors, and exhibits antitumor and anticonvulsant activities. CBC binds weakly to CB1 and CB2 receptors, stimulating cAMP. Research highlights its potential effects, including interference with endocannabinoid breakdown and antitumor actions.

Biosynthesis of Cannabichromene (CBC)

• CBC mainly exists as CBCA in the Cannabis plant
• Geranyl pyrophosphate and olivetolic acid combine to produce CBGA
• CBCA synthase cyclizes CBGA to form CBCA
• CBCA decarboxylates to produce CBC when heated above 93°C
• The biosynthetic scheme of CBC involves these steps

Pharmacological Effects of Cannabichromene (CBC)

• CBC affects THC psychoactivity
• Acts on TRPV1 and TRPA1 receptors
• Shows antitumor effects in breast cancer xenoplants
• Exhibits anticonvulsant activity in a mouse model
• Binds weakly to CB1 and CB2 receptors, acting as an agonist for cAMP stimulation

References and Research on Cannabichromene (CBC)

• Information about CBC is available on PubChem
• Molecular targets of phytocannabinoids are complex
• Studies on the evolution of cannabinoid and terpene content during Cannabis growth
• Research on the neurophysiological and subjective profile of marijuana with varying cannabinoids
• Antitumor activity of plant cannabinoids, including CBC

Potential Effects and Mechanisms of Cannabichromene (CBC)

• CBC may interfere with endocannabinoid breakdown
• Demonstrated antitumor effects in breast cancer xenoplants
• Exhibits anticonvulsant activity in a mouse model
• Binds weakly to CB1 and CB2 receptors
• Acts as an agonist of TRPA1 and less potently TRPV3 and TRPV4

In Vitro and In Vivo Studies on Cannabichromene (CBC)

• CBC has two stereoisomers
• Shown antitumor effects in breast cancer xenoplants in mice
• Acts as an agonist for cAMP stimulation
• Functions as an antagonist at beta-arrestin
• Acts as an agonist of TRPA1, and less potently TRPV3 and TRPV4

Cannabichromene Data Sources